Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385380 | 0.87 | KDR (0.47) | WNT3AKDRCCNE2CCNE1CDK2 | |
| SCHEMBL3176763 | 0.82 | RET (0.53) | WNT3AKDRFLT3 | |
| SCHEMBL13483702 | 0.77 | WNT3A (0.47) | WNT3ACHEK1KDRFLT3CHEK2 | |
| SCHEMBL3380736 | 0.76 | KDR (0.50) | KDRFLT3FGFR3 | |
| SCHEMBL13483161 | 0.76 | WNT3A (0.49) | WNT3AKDRROCK2FLT3FGFR3 | |
| SCHEMBL3380938 | 0.76 | KDR (0.46) | KDRFLT3FGFR3 | |
| SCHEMBL3382431 | 0.76 | KDR (0.44) | KDRFLT3FGFR3 | |
| SCHEMBL3385521 | 0.76 | ALDH1A1 (0.55) | WNT3AKDRFLT3FGFR3 | |
| SCHEMBL3382705 | 0.75 | FGFR3 (0.43) | WNT3AKDRFGFR3 | |
| SCHEMBL3385891 | 0.75 | KDR (0.40) | WNT3AKDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |