Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148608 | 0.84 | NOTUM (0.56) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL4202829 | 0.82 | TP53 (0.52) | ALDH1A1KMT2AMEN1LMNATP53 | |
| SCHEMBL24969695 | 0.75 | ALDH1A1 (0.63) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL30206829 | 0.75 | ALDH1A1 (0.63) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL3386168 | 0.73 | POLB (0.48) | ALDH1A1MAPTHSD17B10CYP1A2POLB | |
| SCHEMBL8063648 | 0.72 | ALDH1A1 (0.82) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL2479024 | 0.71 | ALDH1A1 (0.68) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL8048626 | 0.70 | CYP1A2 (0.76) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL16000906 | 0.70 | ALDH1A1 (0.64) | ALDH1A1GAAKMT2AMEN1LMNA | |
| SCHEMBL13797610 | 0.70 | ALDH1A1 (0.70) | ALDH1A1GAAKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268789-B2 | PAR-2 antagonists | KOWA COMPANY, LTD. (JP) | 2012-09-18 | — | — | US | disclosed |
| EP-1806141-B1 | PAR-2 ANTAGONISTS | KOWA CO (JP) | 2010-12-01 | — | — | EP | disclosed |
| US-20090012263-A1 | Process for Production of (1,3-Disubstituted Indolyl)-Urea Derivatives, Intermediates Therefor, and Process for Production of the Intermediates | KOWA COMPANY, LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012006-A1 | Par-2 Antagonists | KOWA COMPANY, LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1806355-A1 | PROCESS FOR PRODUCTION OF (1,3-DISUBSTITUTED INDOLYL)- UREA DERIVATIVES, INTERMEDIATES THEREFOR, AND PROCESS FOR PRODUCTION OF THE INTERMEDIATES | Kowa Company Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1806141-A1 | PAR-2 ANTAGONISTS | Kowa Company, Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012263-A1 | Process for Production of (1,3-Disubstituted Indolyl)-Urea Derivatives, Intermediates Therefor, and Process for Production of the Intermediates | WEE1, WASF2, IDO1 | ALDH1A1 2230/4885GAA 3918/4885KMT2A 2676/4885 |
| US-20090012006-A1 | Par-2 Antagonists | F2RL1, F2R, F2RL3 | ALDH1A1 3389/4885GAA 3724/4885KMT2A 2113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.