Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 7/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 5/20 | 0.55 |
| ▸ | SELP | P16109 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845029 | 1.00 | HMGCR (0.55) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL2395804 | 1.00 | HMGCR (0.55) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL4148858 | 1.00 | HMGCR (0.55) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL5845890 | 1.00 | HMGCR (0.55) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL5845203 | 1.00 | HMGCR (0.55) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL4130261 | 1.00 | HMGCR (0.55) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL2393399 | 0.97 | — | — | |
| SCHEMBL6408336 | 0.91 | HMGCR (0.57) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL10777606 | 0.91 | HMGCR (0.57) | HMGCRPTPN7SELPRECQLTDP1 | |
| SCHEMBL953771 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119181-A1 | Hydrophobically-modified protein compositions and methods | BIOGEN IDEC INC. (US) | 2005-06-02 | — | — | US | claimed |
| EP-1036092-B1 | Hydrophobically-modified hedgehog protein compositions and methods | BIOGEN INC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1036092-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 2000-09-20 | — | — | EP | claimed |
| WO-1999028343-A9 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN INC (US) | 1999-10-14 | — | — | WO | claimed |
| WO-1999028343-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 1999-06-10 | — | — | WO | claimed |
| US-9321992-B2 | Cell targeting methods and compositions | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150313945-A1 | COMPOSITIONS AND METHODS OF TREATING INFLAMMATORY BOWEL DISEASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-8932852-B2 | Compositions and methods of treating inflammatory bowel disease | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-8906279-B2 | Manufacturing method of polarizing plate protective film, polarizing plate protective film, polarizing plate, and liquid crystal display device | KONICA MINOLTA OPTO, INC. (JP) | 2014-12-09 | — | — | US | disclosed |
| EP-1646395-B1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS INC (US) | 2014-11-05 | — | — | EP | disclosed |
| US-8669346-B2 | Bone marrow targeting peptides | CASE WESTERN RESERVE UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-04 | — | — | US | disclosed |
| WO-2000015246-A2 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999028343-A9 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN INC (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999028343-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1999020298-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999010004-A2 | REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 1999-03-04 | — | — | WO | disclosed |
| US-5801274-A | N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-09-01 | — | — | US | disclosed |
| US-5591891-A | PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-01-07 | — | — | US | disclosed |
| WO-1994017036-A1 | S-LIPOPHILIC ALIPHATIC CARBONYL [N-MERCAPTOACYL-(AMINO ACID OR PEPTIDE)] COMPOUNDS AS ANTIHYPERTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1994-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, FGF1, HGF | HMGCR 3940/4885PTPN7 742/4885SELP 2874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.