Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071507 | 0.83 | AR (0.54) | ARMRGPRX4ACHEKDM4EPGR | |
| SCHEMBL1512534 | 0.80 | ESR1 (0.53) | ACHEKMT2AESR1HIF1ARECQL | |
| SCHEMBL27569649 | 0.80 | ACHE (0.47) | ARACHEKMT2AESR1HIF1A | |
| SCHEMBL29042312 | 0.80 | AR (0.48) | ARMRGPRX4KMT2ACASP1PGR | |
| SCHEMBL11471018 | 0.78 | KMT2A (0.50) | ACHEKMT2AESR1HIF1ARECQL | |
| SCHEMBL9422499 | 0.78 | ESR1 (0.51) | ACHEKMT2AESR1HIF1ARECQL | |
| SCHEMBL4950133 | 0.77 | ALDH1A1 (0.50) | ARMRGPRX4KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27578640 | 0.76 | ESR1 (0.50) | ACHEKMT2AESR1HIF1ARECQL | |
| SCHEMBL10716263 | 0.76 | MAPT (0.50) | ARMRGPRX4KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3291593 | 0.76 | AR (0.41) | ARMRGPRX4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423380-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-1423382-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2008-04-16 | — | — | EP | disclosed |
| US-7279476-B2 | Anticancer agents, antiinflamamtory agents, restenosis, cardiovascular disorders; insertable device | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7183307-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCROPORATED (US) | 2007-02-27 | — | — | US | disclosed |
| US-20050215550-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2005-09-29 | — | — | US | disclosed |
| US-6875789-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040209935-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-21 | — | — | US | disclosed |
| US-6750239-B2 | USEFUL FOR TREATING DISEASE STATES IN MAMMALS THAT ARE ALLEVIATED BY A PROTEIN KINASE INHIBITOR, PARTICULARLY DISEASES SUCH AS CANCER, INFLAMMATORY DISORDERS, RESTENOSIS, AND CARDIOVASCULAR DISEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2004-06-15 | — | — | US | disclosed |
| EP-1423382-A2 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1423380-A1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030144337-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2003-07-31 | — | — | US | disclosed |
| US-20030139452-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2003-07-24 | — | — | US | disclosed |
| WO-2003011855-A2 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-02-13 | — | — | WO | disclosed |
| WO-2003011854-A1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209935-A1 | Pyrazole-derived kinase inhibitors and uses thereof | RAF1, MAP3K1, MAP3K3 | AR 2745/4885MRGPRX4 1034/4885ACHE 4709/4885 |
| US-20050215550-A1 | Pyrazole-derived kinase inhibitors and uses thereof | MAP3K19, MAP3K1, MAP3K3 | AR 2587/4885MRGPRX4 815/4885ACHE 4555/4885 |
| US-20030139452-A1 | Pyrazole-derived kinase inhibitors and uses thereof | RAF1, MAP3K1, MAP3K3 | AR 2990/4885MRGPRX4 891/4885ACHE 4737/4885 |
| US-20030144337-A1 | Pyrazole-derived kinase inhibitors and uses thereof | RAF1, MAP3K1, MAP3K3 | AR 2745/4885MRGPRX4 1034/4885ACHE 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.