Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28068682 | 0.87 | MRGPRX4 (0.48) | ARMRGPRX4LMNAKDM4ECYP3A4 | |
| SCHEMBL29042312 | 0.83 | AR (0.48) | ARMRGPRX4TRPV4PGR | |
| SCHEMBL3387167 | 0.83 | AR (0.48) | ARMRGPRX4TRPV4PGRKDM4E | |
| SCHEMBL27935121 | 0.81 | KDM4E (0.56) | ARLMNAKDM4ECYP3A4ACHE | |
| SCHEMBL2733341 | 0.80 | LMNA (0.43) | ARLMNAKDM4ECYP3A4ACHE | |
| SCHEMBL14366477 | 0.80 | CYP11B2 (0.46) | TRPV4LMNAKDM4ECYP3A4ACHE | |
| SCHEMBL177449 | 0.79 | AR (0.53) | ARMRGPRX4TRPV4PGRKDM4E | |
| SCHEMBL2723599 | 0.79 | AR (0.56) | ARPGRKDM4E | |
| SCHEMBL474037 | 0.78 | AR (0.52) | ARMRGPRX4TRPV4PGR | |
| SCHEMBL11093701 | 0.78 | MRGPRX4 (0.56) | ARMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |
| EP-0860440-A1 | Sulfonamido substituted chromane derivatives with potassium channel blocking activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |