Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.51 |
| ▸ | VNN1 | O95497 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387338 | 1.00 | SCN9A (0.52) | SCN9AGRM3VNN1ALDH1A1GRM5 | |
| SCHEMBL8257885 | 1.00 | SCN9A (0.52) | SCN9AGRM3VNN1ALDH1A1GRM5 | |
| SCHEMBL4024286 | 0.84 | GRM5 (0.58) | ALDH1A1GRM5 | |
| SCHEMBL6265337 | 0.83 | ALDH1A1 (0.64) | GRM3VNN1ALDH1A1GRM5 | |
| SCHEMBL5909199 | 0.83 | ALDH1A1 (0.64) | GRM3VNN1ALDH1A1GRM5 | |
| SCHEMBL1972864 | 0.83 | VNN1 (0.53) | SCN9AVNN1ALDH1A1GRM5RECQL | |
| SCHEMBL1972867 | 0.83 | VNN1 (0.53) | SCN9AVNN1ALDH1A1GRM5RECQL | |
| SCHEMBL2821668 | 0.82 | NPC1 (0.59) | GRM3ALDH1A1GRM5 | |
| SCHEMBL1972661 | 0.82 | NPC1 (0.59) | GRM3ALDH1A1GRM5 | |
| SCHEMBL193622 | 0.82 | NPC1 (0.59) | GRM3ALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809620-B1 | NOVEL TETRAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2010-12-29 | — | — | EP | disclosed |
| US-20070299110-A1 | Novel Tetrazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate | ADDEX PHARMACEUTICALS SA (CH) | 2007-12-27 | — | — | US | disclosed |
| EP-1809620-A1 | NOVEL TETRAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048771-A1 | NOVEL TETRAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299110-A1 | Novel Tetrazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate | GRM5, GRIK5, GRM1 | SCN9A 992/4885GRM3 5/4885VNN1 4637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.