⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705453 | 1.00 | — | — | |
| SCHEMBL8593221 | 0.79 | CASP1 (0.44) | — | |
| SCHEMBL9084392 | 0.79 | CASP1 (0.44) | — | |
| SCHEMBL1291114 | 0.78 | ATM (0.47) | — | |
| SCHEMBL28646277 | 0.78 | ALOX15 (0.39) | — | |
| SCHEMBL28646275 | 0.78 | ALOX15 (0.39) | — | |
| SCHEMBL278041 | 0.77 | — | — | |
| SCHEMBL1878756 | 0.77 | — | — | |
| SCHEMBL20589645 | 0.77 | — | — | |
| SCHEMBL10335471 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423763-A | Regioselective synthesis of imidazo [1,2-a ] pyrimidines | 豪夫迈·罗氏有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-114026092-A | Synthesis of labeled imidazo [1,2-a ] pyrimidines | 豪夫迈·罗氏有限公司 | 2022-02-08 | — | — | CN | disclosed |
| US-20120270864-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB | 2012-10-25 | — | — | US | disclosed |
| US-20100144717-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-06-10 | — | — | US | disclosed |
| EP-2121702-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008120003-A1 | SUBSTITUTED PIPERIDINES FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008071961-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | WO | disclosed |
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4710507-A | Quinolone inotropic agents | PFIZER INC. (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |
| EP-0148623-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1985-07-17 | — | — | EP | disclosed |
| US-RE30024-E | ANTIALLERGENS | STERLING DRUG INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4118571-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-10-03 | — | — | US | disclosed |
| US-4086233-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4032523-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
| US-4018770-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-04-19 | — | — | US | disclosed |