Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 5/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385329 | 0.91 | LMNA (0.44) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL3383431 | 0.85 | ALDH1A1 (0.44) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2368911 | 0.85 | LMNA (0.45) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2368941 | 0.84 | LMNA (0.43) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL3381246 | 0.84 | LMNA (0.43) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL3387596 | 0.83 | LMNA (0.42) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2369179 | 0.83 | HTT (0.38) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2898733 | 0.82 | LMNA (0.51) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2369059 | 0.82 | FGFR1 (0.56) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2369496 | 0.81 | MAPK1 (0.41) | LMNASMN1; SMN2HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249155-B2 | Thieno [2, 3-D] pyrimidine derivatives and their use to treat arrhythmia | XENTION LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| EP-2694518-B1 | THIENO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LTD (GB) | 2015-10-07 | — | — | EP | disclosed |
| US-20140206703-A1 | THIENO [2, 3-D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LIMITED (GB) | 2014-07-24 | — | — | US | disclosed |
| EP-2694518-A1 | THIENO [2, 3 -D]PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | Xention Limited (GB) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012131379-A1 | THIENO [2, 3 -D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LIMITED (GB) | 2012-10-04 | — | — | WO | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| US-20050026935-A1 | Compounds | XENTION DISCOVERY LTD. | 2005-02-03 | — | — | US | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206703-A1 | THIENO [2, 3-D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | KCNJ2, KCNH2, KCNH1 | LMNA 2266/4885SMN1; SMN2 3235/4885HPGD 813/4885 |
| US-20050026935-A1 | Compounds | KCNJ11, KCNJ1, KCNH1 | LMNA 1126/4885SMN1; SMN2 1520/4885HPGD 1231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.