Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | RORA | P35398 | 2/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | GCKR | Q14397 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27961856 | 0.78 | LTA4H (0.42) | PDK2RORBTP53KCNH2 | |
| SCHEMBL3385140 | 0.77 | PDK2 (0.48) | PDK2RORCRORANR1H3NR1H2 | |
| SCHEMBL3084911 | 0.74 | LTA4H (0.47) | — | |
| SCHEMBL28753042 | 0.74 | PDK2 (0.47) | PDK2RORCRORANR1H3NR1H2 | |
| Hydrogen Sulfide SCHEMBL27605763 | 0.73 | LTA4H (0.46) | — | |
| SCHEMBL28507379 | 0.72 | NR1H2 (0.50) | PDK2RORCRORANR1H3NR1H2 | |
| SCHEMBL3385529 | 0.72 | ALDH1A1 (0.50) | PDK2RORCRORANR1H3NR1H2 | |
| SCHEMBL28930463 | 0.72 | ALDH1A1 (0.50) | RORCRORANR1H3NR1H2GCK | |
| SCHEMBL995326 | 0.72 | LTA4H (0.55) | — | |
| SCHEMBL9086705 | 0.72 | ALDH1A1 (0.51) | TP53KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010023317-A1 | NOVEL HEXAFLUORO-2-BIPHENYLISOPROPANOL COMPOUNDS THAT MODULATE LXR-TYPE RECEPTORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS IN HUMAN AND VETERINARY MEDICINE AND ALSO IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-03-04 | — | — | WO | disclosed |