Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30354594 | 0.87 | LMNA (0.47) | MAPTLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28308325 | 0.84 | TSHR (0.48) | LMNATSHRMAPK1HIF1AF2 | |
| SCHEMBL28380754 | 0.83 | ALDH1A1 (0.49) | MAPTLMNATSHRMAPK1HIF1A | |
| SCHEMBL27541022 | 0.83 | CYP2D6 (0.44) | MAPTLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30029663 | 0.81 | L3MBTL1 (0.42) | MAPTLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27320354 | 0.81 | TSHR (0.46) | LMNATSHRMAPK1HIF1AF2 | |
| Methylamine SCHEMBL27679636 | 0.80 | ALDH1A1 (0.46) | MAPTLMNATSHRMAPK1HIF1A | |
| SCHEMBL242716 | 0.80 | LMNA (0.57) | MAPTLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8853090 | 0.78 | LMNA (0.55) | MAPTLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL20531234 | 0.78 | LMNA (0.55) | MAPTLMNACYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327633-B1 | Crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo(5.5.0.0.59O3,11)-dodecane | ALLIANT TECHSYSTEMS INC (US) | 2010-12-15 | — | — | EP | disclosed |
| CN-100366605-C | Compounds to treat alzheimer's disease | ELAN PHARM INC (US) | 2008-02-06 | — | — | CN | disclosed |
| CN-101090883-A | Substituted hydroxyethylamines | ELAN PHARM INC (US) | 2007-12-19 | — | — | CN | disclosed |
| US-7288648-B2 | High temperature crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane | ALLIANT TECHSYSTEMS INC. (US) | 2007-10-30 | — | — | US | disclosed |
| US-20070225493-A1 | Combining CL-20 organic solvent, nonsolvent to form a crystallization solution; saturating the crystallization solution;heating the crystallization solution to a temperature of from about 71 degrees C. to about 94 degrees C.; removing the at least one organic solvent and nonsolvent; separation | NORTHROP GRUMMAN SYSTEMS CORPORATION | 2007-09-27 | — | — | US | disclosed |
| CN-1759095-A | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARM INC (US) | 2006-04-12 | — | — | CN | disclosed |
| US-6992185-B2 | Crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane | ALLIANT TECHSYSTEMS INC. (US) | 2006-01-31 | — | — | US | disclosed |
| CN-1447789-A | Compounds for treating alzheimer's disease | ELAN PHARM INC (US) | 2003-10-08 | — | — | CN | disclosed |
| EP-1327633-A1 | Crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo(5.5.0.0.59O3,11)-dodecane | ALLIANT TECHSYSTEMS INC. (US) | 2003-07-16 | — | — | EP | disclosed |
| US-20030130503-A1 | Crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane | NORTHROP GRUMMAN SYSTEMS CORPORATION | 2003-07-10 | — | — | US | disclosed |