Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31611905 | 0.97 | BBOX1 (0.46) | KDM4ETP53BBOX1SLC18A3LMNA | |
| SCHEMBL1920897 | 0.97 | KDM4E (0.50) | KDM4ETP53BBOX1SLC18A3LMNA | |
| SCHEMBL10256521 | 0.97 | KDM4E (0.50) | KDM4ETP53BBOX1SLC18A3LMNA | |
| Iodide SCHEMBL14778907 | 0.95 | KDM4E (0.54) | KDM4ETP53BBOX1SLC18A3LMNA | |
| Hydrochloric Acid SCHEMBL6420390 | 0.95 | BBOX1 (0.48) | KDM4ETP53BBOX1SLC18A3LMNA | |
| SCHEMBL3817323 | 0.95 | — | — | |
| Iodide SCHEMBL25405847 | 0.92 | KDM4E (0.50) | KDM4ETP53BBOX1SLC18A3LMNA | |
| Hydrochloric Acid SCHEMBL9987512 | 0.92 | BBOX1 (0.50) | KDM4ETP53BBOX1SLC18A3LMNA | |
| SCHEMBL25557911 | 0.89 | — | — | |
| SCHEMBL9987682 | 0.85 | BBOX1 (0.42) | KDM4ETP53BBOX1SLC18A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658842-B2 | Process for producing ethylene glycol catalyzed by ionic liquid | INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES (CN) | 2014-02-25 | — | — | US | disclosed |
| US-20130072727-A1 | PROCESS FOR PRODUCING ETHYLENE GLYCOL CATALYZED BY IONIC LIQUID | INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES (CN) | 2013-03-21 | — | — | US | disclosed |
| US-8097752-B2 | Antiprotozoal ring-substituted phospholipids | MAKSCIENTIFIC, LLC (US) | 2012-01-17 | — | — | US | disclosed |
| EP-1578754-A4 | ANTIPROTOZOAL RING-SUBSTITUTED PHOSPHOLIPIDS | MAKSCIENTIFIC LLC (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20060105998-A1 | Antiprotozoal ring-substiuted phospholipids | MAK SCIENTIFIC CORPORATION (US) | 2006-05-18 | — | — | US | disclosed |
| EP-1578754-A2 | ANTIPROTOZOAL RING-SUBSTITUTED PHOSPHOLIPIDS | MakScientific Corporation (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004041167-A2 | ANTIPROTOZOAL RING-SUBSTITUTED PHOSPHOLIPIDS | CALOGEROPOULOU THEODORA (GR) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060105998-A1 | Antiprotozoal ring-substiuted phospholipids | PHOSPHO1, PLTP, PLA2G2C | CHRM2 3490/4885CHRM4 3654/4885CHRM5 3678/4885 |
| US-20130072727-A1 | PROCESS FOR PRODUCING ETHYLENE GLYCOL CATALYZED BY IONIC LIQUID | AGL, ALKBH3, ELL | CHRM2 2537/4885CHRM4 2715/4885CHRM5 2935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.