Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389771 | 0.94 | LMNA (0.46) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL12448236 | 0.85 | MEN1 (0.40) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL8310563 | 0.79 | KMT2A (0.40) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL23977846 | 0.79 | LMNA (0.44) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL26832966 | 0.79 | LMNA (0.44) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL2700038 | 0.79 | LMNA (0.44) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL12595150 | 0.78 | LMNA (0.41) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL12595149 | 0.78 | LMNA (0.38) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL19955432 | 0.77 | LMNA (0.41) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL1261540 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010018132-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |