Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | ULK1 | O75385 | 4/20 | 0.51 |
| ▸ | ULK2 | Q8IYT8 | 4/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389420 | 0.90 | TBK1 (0.72) | TBK1SYKULK1ULK2CDK2 | |
| SCHEMBL3384644 | 0.90 | SYK (0.63) | TBK1SYKULK1ULK2CDK2 | |
| SCHEMBL3389183 | 0.87 | TBK1 (0.59) | TBK1JAK2JAK1JAK3ULK1 | |
| SCHEMBL3384329 | 0.87 | ULK1 (0.61) | TBK1JAK3ULK1ULK2CDK2 | |
| SCHEMBL3387435 | 0.87 | TBK1 (0.59) | TBK1ULK1ULK2PTK2CDK2 | |
| SCHEMBL3386107 | 0.86 | TBK1 (0.56) | TBK1SYKULK1ULK2NTRK1 | |
| SCHEMBL3387230 | 0.85 | IGF1R (0.52) | TBK1ULK1ULK2BRD4NTRK1 | |
| Trifluoroacetic Acid SCHEMBL3387959 | 0.85 | TBK1 (0.66) | TBK1SYKULK1ULK2CDK2 | |
| SCHEMBL3389438 | 0.84 | TBK1 (0.58) | TBK1JAK3SYKULK1ULK2 | |
| SCHEMBL13431844 | 0.84 | TBK1 (0.83) | TBK1ULK1ULK2CDK2MARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056524-A1 | Compound | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-03-04 | — | — | US | disclosed |
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056524-A1 | Compound | NR3C2, NR3C1, NR2E3 | TBK1 2898/4885JAK2 142/4885JAK1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.