Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.50 |
| ▸ | L3MBTL4 | Q8NA19 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455576 | 0.98 | HPGD (0.66) | HPGDKDM4EALDH1A1TP53HSD11B1 | |
| SCHEMBL1495677 | 0.89 | HPGD (0.60) | HPGDKDM4EALDH1A1TP53HSD11B1 | |
| SCHEMBL18734483 | 0.86 | HPGD (0.57) | HPGDKDM4EALDH1A1TP53HSD11B1 | |
| SCHEMBL1495487 | 0.83 | HPGD (0.54) | HPGDKDM4EALDH1A1TP53TSHR | |
| SCHEMBL3419895 | 0.82 | L3MBTL1 (0.60) | HPGDKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL265991 | 0.81 | HPGD (1.00) | HPGDALDH1A1TP53SMN1; SMN2L3MBTL3 | |
| SCHEMBL14486 | 0.81 | ALDH1A1 (0.50) | HPGDKDM4EALDH1A1TP53L3MBTL3 | |
| SCHEMBL1495813 | 0.81 | SMN1; SMN2 (0.54) | HPGDKDM4EALDH1A1TSHRGAA | |
| SCHEMBL1361761 | 0.80 | HPGD (0.56) | HPGDKDM4EALDH1A1TP53HSD11B1 | |
| SCHEMBL29632673 | 0.80 | HPGD (0.56) | HPGDKDM4EALDH1A1HSD11B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |