Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384448 | 0.84 | PDE10A (0.48) | HTR3APDE10AHRH3PTGES | |
| SCHEMBL3382647 | 0.82 | MCHR1 (0.43) | HTR3APDE10AHRH3CYP3A4 | |
| SCHEMBL3386085 | 0.80 | PDE10A (0.42) | HTR3APDE10AHRH3ALDH1A1HPGD | |
| SCHEMBL3384524 | 0.78 | HRH3 (0.61) | HTR3APDE10AHRH3ALDH1A1CYP1A2 | |
| SCHEMBL3384630 | 0.75 | HRH3 (0.42) | GAAHTR3APDE10AHRH3ALDH1A1 | |
| SCHEMBL15834207 | 0.74 | GAA (0.72) | GAABRD4METAP2HTR3APLAU | |
| SCHEMBL15472859 | 0.74 | GAA (0.72) | GAABRD4METAP2HTR3APLAU | |
| SCHEMBL3384612 | 0.74 | HRH3 (0.41) | GAAHTR3APDE10AHRH3ALDH1A1 | |
| SCHEMBL3570950 | 0.73 | GRIN2B (0.42) | HTR3AHRH3 | |
| SCHEMBL3583955 | 0.73 | HTR3E (0.54) | GAAHTR3AALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984366-B1 | 3, 9-DIAZABICYCLO Ý3.3. 1¨NONANE DERIVATIVES AND THEIR USE AS MONOAMINE?NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH AS (DK) | 2010-12-15 | — | — | EP | claimed |