Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386586 | 0.84 | PDE10A (0.43) | PDE10AMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL3389700 | 0.80 | GAA (0.52) | PDE10AKMT2AHPGDALDH1A1HTR3A | |
| SCHEMBL3384448 | 0.80 | PDE10A (0.48) | PDE10AHTR3AHRH3 | |
| SCHEMBL3382647 | 0.78 | MCHR1 (0.43) | PDE10ANPC1RAB9AHTR3AHRH3 | |
| SCHEMBL3384524 | 0.74 | HRH3 (0.61) | PDE10AALDH1A1MAPK1TDP1HTT | |
| SCHEMBL3386080 | 0.74 | ALDH1A1 (0.58) | MAPTALDH1A1LMNANPSR1HTR3A | |
| SCHEMBL20340591 | 0.74 | GAA (0.60) | PDE10AHPGDMAPTALDH1A1MAPK1 | |
| SCHEMBL3570950 | 0.70 | GRIN2B (0.42) | MAPK1HTR3AHRH3 | |
| SCHEMBL3583955 | 0.70 | HTR3E (0.54) | MEN1KMT2AHPGDALDH1A1HTR3A | |
| SCHEMBL3574947 | 0.69 | HRH3 (0.43) | PDE10AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984366-B1 | 3, 9-DIAZABICYCLO Ý3.3. 1¨NONANE DERIVATIVES AND THEIR USE AS MONOAMINE?NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH AS (DK) | 2010-12-15 | — | — | EP | claimed |