Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | SPR | P35270 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | RAC1 | P63000 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388954 | 0.93 | HTR1D (0.53) | HTR1DSPRMAPTIP6K1RAC1 | |
| SCHEMBL3390345 | 0.87 | HTR1D (0.55) | HTR1DSPRMAPTIP6K1KDM4E | |
| SCHEMBL3388179 | 0.82 | HTR1A (0.49) | MAPTRAC1MEN1KMT2AHTR1A | |
| SCHEMBL31379883 | 0.82 | HTR1A (0.49) | MAPTRAC1MEN1KMT2AHTR1A | |
| SCHEMBL23069123 | 0.72 | HTR1D (1.00) | HTR1DMAPTKDM4EHTR2CSLC6A4 | |
| SCHEMBL2599242 | 0.72 | HTR2C (0.47) | HTR1DSPRMAPTIP6K1KDM4E | |
| SCHEMBL13019374 | 0.70 | HTR2A (0.51) | MAPTIP6K1KDM4EMEN1KMT2A | |
| SCHEMBL25076904 | 0.69 | HTR2C (0.64) | HTR1DSPRMAPTKDM4EHTR2C | |
| SCHEMBL23069155 | 0.67 | HTR1D (0.73) | HTR1DSPRMAPTKDM4EHTR2C | |
| SCHEMBL24243759 | 0.67 | HTR1D (0.90) | HTR1DMAPTKDM4EHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | claimed |
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | disclosed |
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | disclosed |