Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 4/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164715 | 0.91 | MAPK14 (0.58) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL3170506 | 0.90 | MAPK14 (0.57) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL3392491 | 0.84 | KCNJ6 (0.48) | MAPK14TNFBRAFMAPK13MAPK12 | |
| SCHEMBL3390169 | 0.83 | MAPK14 (0.49) | MAPK14TNFBRAFMAPK13MAPK12 | |
| SCHEMBL27720483 | 0.83 | MAPK14 (0.46) | MAPK14TNFBRAFMAPK13MAPK12 | |
| SCHEMBL27720462 | 0.83 | MAPK14 (0.51) | MAPK14TNFBRAFMAPK13MAPK12 | |
| SCHEMBL3421992 | 0.82 | MAPK14 (0.49) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL3388074 | 0.82 | MAPK14 (0.49) | MAPK14TNFBRAFMAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL3164661 | 0.82 | MAPK14 (0.51) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL3415918 | 0.82 | BRAF (0.47) | MAPK14TNFBRAFMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |