Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139046 | 0.87 | ALDH1A1 (0.44) | NPSR1ALDH1A1HSD17B10MAPK1PGR | |
| SCHEMBL1471745 | 0.85 | KDM4E (0.45) | ALDH1A1HSD17B10PLK1KDM4EHPGD | |
| SCHEMBL28546281 | 0.85 | KDM4E (0.45) | ALDH1A1HSD17B10PLK1KDM4EHPGD | |
| SCHEMBL27702983 | 0.85 | KDM4E (0.45) | ALDH1A1HSD17B10PLK1KDM4EHPGD | |
| SCHEMBL24821171 | 0.80 | PLCG1 (0.47) | MAPTNPSR1ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL10412004 | 0.78 | ALDH1A1 (0.44) | MAPTNPSR1ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL8563130 | 0.78 | ALDH1A1 (0.44) | MAPTNPSR1ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL9087816 | 0.77 | ALDH1A1 (0.43) | MAPTNPSR1ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL27616337 | 0.77 | ALDH1A1 (0.44) | MAPTNPSR1ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL9088372 | 0.77 | ALDH1A1 (0.43) | MAPTNPSR1ALDH1A1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758844-B1 | PHOSPHINE-PHOSPHORAMIDITE COMPOUNDS | JOHNSON MATTHEY PLC (GB) | 2010-12-15 | — | — | EP | disclosed |
| EP-1758844-A1 | PHOSPHINE-PHOSPHORAMIDITE COMPOUNDS | EASTMAN CHEMICAL COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006012045-A1 | PHOSPHINE-PHOSPHORAMIDITE COMPOUNDS | EASTMAN CHEMICAL COMPANY (US) | 2006-02-02 | — | — | WO | disclosed |
| EP-1330464-B1 | PHOSPHINO-AMINOPHOSPHINES, CATALYST COMPLEXES AND ENANTIOSELECTIVE HYDROGENATION | EASTMAN CHEM CO (US) | 2005-11-16 | — | — | EP | disclosed |
| US-6906212-B1 | Phosphine-phosphoramidite compounds | EASTMAN CHEMICAL COMPANY (US) | 2005-06-14 | — | — | US | disclosed |
| EP-1330464-A2 | PHOSPHINO-AMINOPHOSPHINES, CATALYST COMPLEXES AND ENANTIOSELECTIVE HYDROGENATION | EASTMAN CHEMICAL COMPANY (US) | 2003-07-30 | — | — | EP | disclosed |
| US-6590115-B2 | Useful as ligands for metal catalysts for asymmetric reactions, in particular as rhodium complexes for asymmetric hydrogenation of enamide, itaconate, and alpha-ketoester compounds | EASTMAN CHEMICAL COMPANY | 2003-07-08 | — | — | US | disclosed |
| US-20020065417-A1 | Useful as ligands for metal catalysts for asymmetric reactions, in particular as rhodium complexes for asymmetric hydrogenation of enamide, itaconate, and alpha-ketoester compounds | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2002-05-30 | — | — | US | disclosed |
| WO-2002026750-A2 | PHOSPHINO-AMINOPHOSPHINES, CATALYST COMPLEXES AND ENANTIOSELECTIVE HYDROGENATION | EASTMAN CHEMICAL COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065417-A1 | Useful as ligands for metal catalysts for asymmetric reactions, in particular as rhodium complexes for asymmetric hydrogenation of enamide, itaconate, and alpha-ketoester compounds | NOTUM, WEE1, WEE2 | MAPT 4067/4885NPSR1 1660/4885ALDH1A1 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.