SCHEMBL3390519

SCHEMBL3390519

C1=NC=NCN1c1ccccn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLD1 Q13393 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.37
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2A Q12879 1/20 0.37
GRIN2B Q13224 1/20 0.37
GRIN2C Q14957 1/20 0.37
GRIN3A Q8TCU5 1/20 0.37
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.35
EP300 Q09472 1/20 0.35
KAT2B Q92831 1/20 0.35
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 2/20 0.35
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
CRBN Q96SW2 1/20 0.35
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6369470 0.77 HPGD (0.38) SMN1; SMN2KDM4EHPGDRAB9AMEN1
SCHEMBL5145918 0.71 PLD1 (0.43) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
SCHEMBL5145920 0.71 PLD1 (0.40) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
SCHEMBL5256809 0.70 PLD1 (0.46) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
SCHEMBL3078996 0.70 GRIN2B (0.46) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
SCHEMBL1140766 0.69 PLD1 (0.47) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
SCHEMBL6654238 0.68 LTA4H (0.41) SMN1; SMN2MEN1TSHRKMT2A
Hydrochloric Acid SCHEMBL3827230 0.67 PLD1 (0.46) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
Bromide SCHEMBL6883560 0.66 PLD1 (0.44) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1
SCHEMBL9091364 0.64 SMN1; SMN2 (0.44) PLD1SMN1; SMN2GRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010514-B1 3-(PYRIDIN-2-YL)-[1,2,4]-TRIAZINES FOR USE AS FUNGICIDES BASF SE (DE) 2010-12-29 EP disclosed
US-20090111692-A1 3-(Pyridin-2-Yl)-[1,2,4]-Triazines as Fungicides BASF AKTIENGESELLSCHAFT (DE) 2009-04-30 US disclosed
EP-2010514-A1 3-(PYRIDIN-2-YL)-[1,2,4]-TRIAZINES FOR USE AS FUNGICIDES BASF SE (DE) 2009-01-07 EP disclosed
WO-2007116078-A1 3-(PYRIDIN-2-YL)-[1,2,4]-TRIAZINES FOR USE AS FUNGICIDES BASF SE (DE) 2007-10-18 WO disclosed
US-4868178-A FUNGICIDE SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1989-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090111692-A1 3-(Pyridin-2-Yl)-[1,2,4]-Triazines as Fungicides CBR3, CBR1, TH PLD1 698/4885SMN1; SMN2 4404/4885GRIN2D 2410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.