Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175386 | 0.87 | KDM4E (0.38) | L3MBTL1RAB9AMAPK14KDM4EMAPK13 | |
| SCHEMBL3389956 | 0.86 | RAB9A (0.36) | PANK3L3MBTL1RAB9AMAPK14KDM4E | |
| SCHEMBL3390558 | 0.86 | MAPK13 (0.40) | L3MBTL1RAB9AMAPK14KDM4EMAPK13 | |
| SCHEMBL3390567 | 0.83 | MAPK14 (0.53) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL3390498 | 0.83 | RAB9A (0.36) | PANK3L3MBTL1RAB9AMAPK14MAPK13 | |
| SCHEMBL3180045 | 0.82 | MAPK14 (0.56) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL4602876 | 0.80 | MAPK14 (0.42) | MAPK14KDM4EMAPK13SMN1; SMN2MAPK9 | |
| SCHEMBL4602779 | 0.79 | MAPK13 (0.45) | MAPK14MAPK13SMN1; SMN2MAPK9MAPK12 | |
| SCHEMBL4602880 | 0.78 | MAPK14 (0.43) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL3390651 | 0.78 | SMO (0.37) | MAPK14KDM4EMAPK13SMN1; SMN2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |