Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602876 | 0.90 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL4602779 | 0.90 | MAPK13 (0.45) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL4603475 | 0.87 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL2953750 | 0.87 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3180430 | 0.86 | CDK8 (0.35) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3390651 | 0.86 | SMO (0.37) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3391079 | 0.86 | RBP4 (0.35) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3392905 | 0.85 | SMO (0.39) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3389956 | 0.82 | RAB9A (0.36) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3390558 | 0.81 | MAPK13 (0.40) | MAPK14MAPK13CYP2C9MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |