Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602880 | 0.90 | MAPK14 (0.43) | MAPK13MAPTMAPK14MAPK12MAPK11 | |
| SCHEMBL4602876 | 0.89 | MAPK14 (0.42) | MAPK13MAPTSMN1; SMN2MAPK14NAMPT | |
| SCHEMBL3390558 | 0.89 | MAPK13 (0.40) | MAPK13MAPTMAPK1SMN1; SMN2MAPK14 | |
| SCHEMBL4603475 | 0.87 | MAPK14 (0.40) | MAPK13MAPTSMN1; SMN2MAPK14MAPK12 | |
| SCHEMBL2953750 | 0.86 | MAPK14 (0.40) | MAPK13MAPTMAPK1MAPK14MAPK12 | |
| SCHEMBL3392858 | 0.83 | MALT1 (0.38) | MAPK13MAPK14PTK2 | |
| SCHEMBL4602777 | 0.81 | MAPK14 (0.66) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL3175386 | 0.81 | KDM4E (0.38) | MAPK13MAPTMAPK14NAMPTMAPK12 | |
| SCHEMBL3389956 | 0.80 | RAB9A (0.36) | MAPK13MAPTSMN1; SMN2MAPK14MAPK12 | |
| SCHEMBL3390498 | 0.79 | RAB9A (0.36) | MAPK13MAPTMAPK14MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |