Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.48 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9696460 | 0.82 | PPARA (0.58) | PPARGPPARAKMT2AALDH1A1CYP3A4 | |
| SCHEMBL9858289 | 0.80 | PPARG (0.51) | PPARGPPARAKMT2AALDH1A1CYP3A4 | |
| SCHEMBL6478045 | 0.75 | PTGDR2 (0.39) | KMT2AALDH1A1HTTLMNAPLA2G2C | |
| SCHEMBL4257140 | 0.73 | PPARG (0.65) | PPARGPPARACTRC | |
| SCHEMBL2276993 | 0.70 | PPARG (0.40) | PPARGPPARACTRC | |
| SCHEMBL3391356 | 0.70 | GAA (0.52) | KMT2AMMP1ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL8935844 | 0.70 | SMN1; SMN2 (0.70) | PPARGPPARA | |
| SCHEMBL8935859 | 0.70 | SMN1; SMN2 (0.70) | PPARGPPARA | |
| SCHEMBL1171344 | 0.70 | SMN1; SMN2 (0.70) | PPARGPPARA | |
| SCHEMBL9696465 | 0.70 | PPARA (0.55) | PPARGPPARACTRCTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317689-A1 | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety | ALEVIUM PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100113524-A1 | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety | ALEVIUM PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
| WO-2008036201-A1 | PRODRUGS OF PROTON PUMP INHIBITORS INCLUDING THE 1H-IMIDAZO[4,5-B] PYRIDINE MOIETY | ALEVIUM PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036211-A1 | PRODRUGS OF PROTON PUMP INHIBITORS INCLUDING THE (1H-PYRROL-1-YL)-1H-BENZIMIDAZOLE MOIETY | ALEVIUM PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317689-A1 | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety | ABCB11, ATP6AP1, CYP4B1 | PPARG 2401/4885PPARA 2721/4885KMT2A 1889/4885 |
| US-20100113524-A1 | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety | ABCB11, ATP6AP1, PAH | PPARG 1952/4885PPARA 2499/4885KMT2A 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.