Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.51 |
| ▸ | PPARA | Q07869 | 13/20 | 0.51 |
| ▸ | CTRC | Q99895 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9696460 | 0.89 | PPARA (0.58) | PPARGPPARACTRCALDH1A1CYP3A4 | |
| SCHEMBL10419468 | 0.81 | PPARG (0.67) | PPARGPPARACTRC | |
| SCHEMBL3391374 | 0.80 | PPARG (0.48) | PPARGPPARACTRCALDH1A1CYP3A4 | |
| SCHEMBL9613979 | 0.79 | PPARG (0.63) | PPARGPPARACTRCALDH1A1KMT2A | |
| SCHEMBL27277079 | 0.78 | CTRC (0.56) | PPARGPPARACTRC | |
| SCHEMBL9614177 | 0.78 | PPARG (0.61) | PPARGPPARACTRCALDH1A1KMT2A | |
| SCHEMBL11576734 | 0.77 | CTRC (0.58) | PPARGPPARACTRC | |
| SCHEMBL9858462 | 0.77 | MMP2 (0.54) | ALDH1A1CYP3A4CYP2C9CYP2C19HSD11B1 | |
| SCHEMBL9696465 | 0.77 | PPARA (0.55) | PPARGPPARACTRC | |
| SCHEMBL9614136 | 0.76 | PPARG (0.56) | PPARGPPARACTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1018548-B | CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-07 | — | — | CN | disclosed |
| EP-0279162-B1 | CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1991-06-19 | — | — | EP | disclosed |
| EP-0279162-A1 | Carbonic acid derivatives, process for their preparation and pharmaceuticals containing them | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |
| CN-88100219-A | New carboxylic acid derivative and preparation technology thereof and the medicinal compositions that contains these derivatives | — | 1988-07-27 | — | — | CN | disclosed |