Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391400 | 0.77 | ALDH1A1 (0.39) | ALDH1A1GAAAKR1C3AKR1C1LMNA | |
| SCHEMBL14305129 | 0.73 | SPR (0.49) | SPRNAMPTHTR2AKCNH2HTR2C | |
| SCHEMBL4155933 | 0.72 | SPR (0.52) | SPRNAMPTHTR2AKCNH2HTR2C | |
| SCHEMBL27575531 | 0.72 | HPGD (0.49) | ALDH1A1GAAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL10806766 | 0.72 | GAA (0.56) | SPRHTR2AMGLLALDH1A1GAA | |
| SCHEMBL27917812 | 0.70 | HTR2A (0.58) | SPRHTR2AKCNH2HTR2CALDH1A1 | |
| SCHEMBL19293992 | 0.69 | GAA (0.62) | SPRHTR2AKCNH2HTR2CMGLL | |
| SCHEMBL20233339 | 0.68 | KAT6A (0.53) | SPRNAMPTHTR2AKCNH2HTR2C | |
| SCHEMBL8546806 | 0.68 | AKR1C3 (0.51) | SPRALDH1A1GAAAKR1C3AKR1C1 | |
| SCHEMBL17689403 | 0.68 | HTR2A (0.55) | SPRNAMPTHTR2AKCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |