Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824065 | 0.82 | ESR1 (0.54) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| Hordenine SCHEMBL19896488 | 0.76 | HRH3 (0.67) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| SCHEMBL9524242 | 0.76 | ESR1 (0.59) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| SCHEMBL9695246 | 0.76 | ESR1 (0.59) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| Hordenine SCHEMBL36798 | 0.76 | HRH3 (0.67) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| SCHEMBL69344 | 0.76 | ESR1 (1.00) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| SCHEMBL3873458 | 0.76 | ESR1 (1.00) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| SCHEMBL3377935 | 0.75 | TAAR1 (0.58) | ALDH1A1ADRA2ASLC6A2HTR1ATAAR1 | |
| Hordenine SCHEMBL2478680 | 0.74 | HRH3 (0.64) | ESR1ESR2CA2ALDH1A1ADRA2A | |
| Hordenine SCHEMBL11147428 | 0.74 | HRH3 (0.64) | ESR1ESR2CA2ALDH1A1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086167-A | Ion exchanging with a ligand/matrix using a combination of pi-electron and electrostatic interaction of the ligand and ionic amino acids | UNIVERSITY OF MIAMI (US) | 1992-02-04 | — | — | US | claimed |
| EP-0371746-A2 | Method of separating proteins | UNIVERSITY OF MIAMI (US) | 1990-06-06 | — | — | EP | claimed |
| US-8158438-B2 | Method for the determination of the concentration of a non-volatile analyte | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8097725-B2 | Luminescent indicator dye and optical sensor | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-1899712-B1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF A NON-VOLATILE ANALYTE | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-1817290-B1 | LUMINESCENT INDICATOR DYE AND OPTICAL SENSOR | ROCHE DIAGNOSTICS GMBH (DE) | 2008-11-12 | — | — | EP | disclosed |
| US-20080215254-A1 | Method for the Determination of the Concentration of a Non-Volatile Analyte | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| EP-1899712-A1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF A NON-VOLATILE ANALYTE | F. Hoffmann-Roche AG (CH) | 2008-03-19 | — | — | EP | disclosed |
| EP-1817290-A2 | LUMINESCENT INDICATOR DYE AND OPTICAL SENSOR | Roche Diagnostics GmbH (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007006454-A1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF A NON-VOLATILE ANALYTE | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |
| EP-1742039-A1 | Method for the determination of the concentration of a non-volatile analyte | F. Hoffmann-La Roche Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006058778-A2 | LUMINESCENT INDICATOR DYE AND OPTICAL SENSOR | ROCHE DIAGNOSTICS GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |
| US-20060121623-A1 | Luminescent indicator dye and optical sensor | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2006-06-08 | — | — | US | disclosed |
| US-5110914-A | Ion exchanging | UNIVERSITY OF MIAMI (US) | 1992-05-05 | — | — | US | disclosed |
| US-5086167-A | Ion exchanging with a ligand/matrix using a combination of pi-electron and electrostatic interaction of the ligand and ionic amino acids | UNIVERSITY OF MIAMI (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0371746-A2 | Method of separating proteins | UNIVERSITY OF MIAMI (US) | 1990-06-06 | — | — | EP | disclosed |