Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 15/20 | 0.61 |
| ▸ | POLQ | O75417 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393227 | 0.81 | PYCR1 (0.63) | PYCR1LMNAUSP2CYP3A4TSHR | |
| SCHEMBL3394172 | 0.76 | PYCR1 (1.00) | PYCR1LMNAUSP2CYP3A4TSHR | |
| SCHEMBL2324597 | 0.73 | DAO (0.48) | PYCR1POLQ | |
| SCHEMBL25594632 | 0.70 | CYP2C19 (0.64) | POLQCYP3A4 | |
| SCHEMBL4416164 | 0.70 | POLQ (0.51) | POLQALDH1A1 | |
| SCHEMBL1538523 | 0.69 | DAO (0.49) | POLQ | |
| SCHEMBL1993639 | 0.68 | CES2 (0.52) | POLQCYP3A4 | |
| SCHEMBL13349970 | 0.67 | DAO (0.51) | POLQ | |
| SCHEMBL13644756 | 0.67 | POLQ (0.46) | POLQCYP3A4 | |
| SCHEMBL964552 | 0.67 | DAO (0.46) | POLQTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |