Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.69 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MST1R | Q04912 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488259 | 0.82 | MET (0.46) | METSRCKDRKITFGFR2 | |
| SCHEMBL488751 | 0.81 | MET (1.00) | METSRCKDRKITFGFR2 | |
| SCHEMBL3120131 | 0.81 | MET (1.00) | METSRCKDRKITFGFR2 | |
| SCHEMBL15133818 | 0.81 | MET (1.00) | METSRCKDRKITFGFR2 | |
| SCHEMBL29529122 | 0.81 | MET (1.00) | METSRCKDRKITFGFR2 | |
| SCHEMBL30453522 | 0.81 | JAK2 (0.74) | METJAK2INPPL1 | |
| SCHEMBL28607434 | 0.79 | MET (0.57) | METSRCKDRKITFGFR2 | |
| SCHEMBL27650269 | 0.79 | MET (0.60) | METSRCKDRKITFGFR2 | |
| SCHEMBL31494646 | 0.77 | MET (0.66) | METSRCKDRKITFGFR2 | |
| SCHEMBL3113351 | 0.77 | MET (0.66) | METSRCKDRKITFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784396-B1 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-12-22 | — | — | EP | disclosed |