Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 15/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390252 | 0.86 | TGFBR1 (0.40) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL3392992 | 0.85 | TGFBR1 (0.39) | PIM1PIM2FLT3PIM3IDO1 | |
| Hydrochloric Acid SCHEMBL14877110 | 0.84 | TGFBR1 (0.39) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL3385827 | 0.82 | POLB (0.41) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL3390023 | 0.82 | TGFBR1 (0.40) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL244421 | 0.82 | KDR (0.47) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL3383905 | 0.82 | TGFBR1 (0.41) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL12440185 | 0.81 | TGFBR1 (0.41) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL247224 | 0.81 | TBK1 (0.46) | PIM1PIM2FLT3PIM3IDO1 | |
| SCHEMBL21756156 | 0.81 | TGFBR1 (0.39) | PIM1PIM2FLT3PIM3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000595-A1 | 2,4- DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |