Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 8/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 8/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 8/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SIGLEC9 | Q9Y336 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390673 | 0.88 | KCNJ6 (0.38) | KCNJ6KCNJ5KCNJ3BRAFKMT2A | |
| SCHEMBL3392430 | 0.88 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3LMNABRAF | |
| SCHEMBL3392130 | 0.86 | KCNJ6 (0.41) | KCNJ6KCNJ5KCNJ3RAB9ASIGLEC9 | |
| SCHEMBL3392551 | 0.85 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3RAB9ASIGLEC9 | |
| SCHEMBL3393260 | 0.81 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3LMNABRAF | |
| SCHEMBL3388802 | 0.81 | KCNJ6 (0.41) | KCNJ6KCNJ5KCNJ3LMNABRAF | |
| SCHEMBL3392536 | 0.77 | LMNA (0.34) | RAB9ASIGLEC9LMNABRAFKMT2A | |
| SCHEMBL3390667 | 0.73 | KCNJ6 (0.45) | KCNJ6KCNJ5KCNJ3BRAFKMT2A | |
| SCHEMBL3392533 | 0.73 | MAPK14 (0.44) | BRAF | |
| SCHEMBL3422863 | 0.73 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |