Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF known ✓ | P15056 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720483 | 0.97 | MAPK14 (0.46) | MAPK14TNFDDR2BRAFPTK2B | |
| SCHEMBL3389740 | 0.92 | PTK2B (0.50) | MAPK14DDR2BRAFPTK2BMAPK13 | |
| SCHEMBL3392130 | 0.87 | KCNJ6 (0.41) | MAPK14TNFBRAF | |
| SCHEMBL3415918 | 0.86 | BRAF (0.47) | MAPK14TNFDDR2BRAFPTK2B | |
| SCHEMBL3391154 | 0.85 | MAPK14 (0.47) | MAPK14TNFDDR2BRAFPTK2B | |
| SCHEMBL3389724 | 0.85 | MAPK14 (0.49) | MAPK14TNFDDR2BRAFPTK2B | |
| SCHEMBL3392536 | 0.85 | LMNA (0.34) | MAPK14TNFDDR2BRAF | |
| SCHEMBL3392551 | 0.84 | KCNJ6 (0.42) | MAPK14TNFBRAFPTK2B | |
| SCHEMBL3390169 | 0.82 | MAPK14 (0.49) | MAPK14TNFDDR2BRAFPTK2B | |
| SCHEMBL27720462 | 0.82 | MAPK14 (0.51) | MAPK14TNFDDR2BRAFPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |