Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141854 | 0.85 | KDM4E (0.36) | ALDH1A1HCAR2FBP1GABRG2GABRB3 | |
| SCHEMBL3128705 | 0.83 | GNE (0.40) | ALDH1A1LMNATSHR | |
| SCHEMBL4489665 | 0.82 | HPGD (0.41) | ALDH1A1LMNATSHR | |
| SCHEMBL3141845 | 0.77 | CDK4 (0.40) | ALDH1A1GABRG2GABRB3GABRA2 | |
| SCHEMBL4108395 | 0.73 | PPARA (0.37) | GABRA1SGK1CAMKK2 | |
| SCHEMBL3942372 | 0.72 | HCAR2 (0.43) | HCAR2HCAR3GABRA1TSHRDAO | |
| SCHEMBL23340760 | 0.71 | MAPT (0.36) | ALDH1A1HCAR2HCAR3GABRA1GABRB2 | |
| SCHEMBL28450135 | 0.71 | KDM4E (0.42) | FBP1TSHR | |
| SCHEMBL3493488 | 0.70 | CNR1 (0.41) | GABRG2GABRB3GABRA2 | |
| SCHEMBL3493482 | 0.70 | CNR1 (0.41) | GABRG2GABRB3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE | 2010-05-06 | — | — | US | disclosed |
| WO-2010042758-A2 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-04-15 | — | — | WO | disclosed |
| WO-2009020603-A9 | UPP AMPHIPHILIC ALPHA-HELIX MIMETICS | SCRIPPS RESEARCH INST (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009020603-A2 | UPP AMPHIPHILIC ALPHA-HELIX MIMETICS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | OXA1L, H1-4, H1-5 | ALDH1A1 1322/4885HCAR2 541/4885HCAR3 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.