Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.37 |
| ▸ | CHUK | O15111 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395806 | 0.86 | IKBKB (0.39) | IKBKBCHUKDYRK1APROKR1AURKA | |
| SCHEMBL3393092 | 0.83 | IKBKB (0.54) | IKBKBCHUKWNT1DYRK1AAURKA | |
| SCHEMBL3395593 | 0.80 | IKBKB (0.32) | IKBKBCHUKPGRCYP2D6CYP2C9 | |
| SCHEMBL3391403 | 0.70 | IKBKB (0.69) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL3392308 | 0.70 | IKBKB (0.53) | IKBKBCHUKWNT1DYRK1AAURKA | |
| SCHEMBL3395187 | 0.69 | IKBKB (0.57) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL3392939 | 0.69 | IKBKB (0.56) | IKBKBCHUKDYRK1AAURKAFLT3 | |
| SCHEMBL3396364 | 0.69 | IKBKB (0.54) | IKBKBCHUKWNT1DYRK1AAURKA | |
| SCHEMBL4664952 | 0.68 | IKBKB (0.51) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL3391379 | 0.68 | HPGDS (0.45) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501780-B2 | Indazole carboxamides and their use | GLAXOSMITHKLINE LLC (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501780-B2 | Indazole carboxamides and their use | GLAXOSMITHKLINE LLC (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501780-B2 | Indazole carboxamides and their use | GLAXOSMITHKLINE LLC (US) | 2013-08-06 | — | — | US | disclosed |
| EP-1758578-B1 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | GLAXOSMITHKLINE LLC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-1758578-B1 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | GLAXOSMITHKLINE LLC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-1758578-A4 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | SMITHKLINE BEECHAM CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-06 | — | — | US | disclosed |
| CN-101005836-A | Novel indazole carboxamides and their use | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | CN | disclosed |
| EP-1758578-A2 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | Smithkline Beecham Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006002434-A2 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | IKBKG, IRAK2, NFKBIA | IKBKB 8/4885CHUK 9/4885WNT1 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.