Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PPIA | P62937 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388784 | 0.81 | CYP17A1 (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL10055039 | 0.80 | NPC1 (0.68) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL17831084 | 0.80 | KMT2A (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1750737 | 0.80 | NR4A2 (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL29816629 | 0.79 | ALDH1A1 (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL223680 | 0.79 | ALDH1A1 (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL3388031 | 0.78 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL9975274 | 0.78 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL16188933 | 0.78 | FFAR1 (0.65) | NPC1ALDH1A1CYP2D6CYP2C19 | |
| Formaldehyde SCHEMBL29285221 | 0.77 | CYP2C19 (0.56) | NPC1ALDH1A1CYP2D6CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207547-A2 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | Amira Pharmaceuticals, Inc. (US) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009045700-A2 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |