Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20983221 | 0.85 | POLB (0.52) | CA2CA12CA1CA7CA9 | |
| SCHEMBL39025 | 0.80 | CA12 (0.45) | CA2CA12CA1CA7CA9 | |
| SCHEMBL39033 | 0.77 | PTPN1 (0.54) | CA2CA12CA1CA7CA9 | |
| SCHEMBL9064155 | 0.76 | CA1 (0.41) | CA2CA12CA1CA7CA9 | |
| SCHEMBL39761 | 0.76 | CA12 (0.41) | CA2CA12CA1CA7CA9 | |
| SCHEMBL39571 | 0.74 | KAT8 (0.50) | PTPN1PTPN11KDM4EHPGDCYP3A4 | |
| SCHEMBL22660353 | 0.74 | CA12 (0.40) | CA2CA12CA1CA7CA9 | |
| SCHEMBL14968363 | 0.72 | TAAR1 (0.50) | CA2CA12CA1CA7CA9 | |
| SCHEMBL29002747 | 0.72 | KDM4E (0.56) | CA2CA12CA1CA7CA9 | |
| SCHEMBL3886521 | 0.72 | ALDH1A1 (0.54) | CA2CA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
| WO-2006047740-A2 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2006-05-04 | — | — | WO | disclosed |
| US-20060089495-A1 | Heat shock protein 90 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089495-A1 | Heat shock protein 90 inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | CA2 4190/4885CA12 4772/4885CA1 4406/4885 |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | CA2 4190/4885CA12 4772/4885CA1 4406/4885 |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | HSP90AB2P, HSPH1, HSP90AA1 | CA2 4053/4885CA12 4694/4885CA1 4126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.