Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644126 | 0.84 | NPC1 (0.46) | HTTMEN1KMT2AMAPTRAB9A | |
| SCHEMBL190518 | 0.82 | PLAAT3 (0.48) | HTTMEN1KMT2APIN1HAO1 | |
| SCHEMBL3406189 | 0.78 | SCN9A (0.50) | HTTMEN1KMT2AHAO1MAPT | |
| SCHEMBL30350812 | 0.78 | SCN9A (0.50) | HTTMEN1KMT2AHAO1MAPT | |
| SCHEMBL19510741 | 0.78 | MAP4K4 (0.49) | HTTMEN1KMT2AMAPTGAA | |
| SCHEMBL4822084 | 0.78 | KDR (0.54) | HTTMEN1KMT2AHAO1RAB9A | |
| SCHEMBL3277080 | 0.77 | RAB9A (0.45) | HTTMAPTLMNARAB9APLAAT3 | |
| SCHEMBL16654773 | 0.77 | KDM4E (0.39) | HTTMEN1KMT2AHAO1GAA | |
| SCHEMBL19089468 | 0.77 | ALDH1A1 (0.51) | HTTMEN1KMT2APIN1MAPT | |
| SCHEMBL5377932 | 0.77 | MAOB (0.49) | MEN1KMT2AMAPTGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | disclosed |