Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.48 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.48 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.48 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.48 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.48 |
| ▸ | CHKA known ✓ | P35790 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 4/20 | 0.61 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CASP1 | P29466 | 2/20 | 0.56 |
| ▸ | HBB | P68871 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL339321 | 1.00 | KDM4A (0.61) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL10104166 | 0.98 | KDM4A (0.63) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL19903920 | 0.92 | KDM4A (0.61) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL12201183 | 0.91 | KDM4A (0.58) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL10313125 | 0.90 | KDM4A (0.56) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL19649090 | 0.87 | KDM4A (0.61) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL10104197 | 0.86 | KDM4A (0.74) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL10104442 | 0.86 | KDM4A (0.74) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL14984144 | 0.86 | KDM4A (0.73) | KDM4AKDM2AMEN1KMT2AMAPT | |
| SCHEMBL10104220 | 0.86 | KDM4A (0.50) | KDM4AKDM2AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140033450-A1 | METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DEISULPHIDE DYE | L'OREAL (FR) | 2014-02-06 | — | — | US | disclosed |
| US-8562693-B2 | Method of dyeing and lightening keratin materials in the presence of a reducing agent comprising a fluorescent deisulphide dye | L'OREAL (FR) | 2013-10-22 | — | — | US | disclosed |
| US-20130074276-A1 | METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE | L'OREAL S.A. (FR) | 2013-03-28 | — | — | US | disclosed |
| US-8328880-B2 | Method of colouring and lightening keratin materials in the presence of a reducing agent comprising a fluorescent disulphide dye | L'OREAL (FR) | 2012-12-11 | — | — | US | disclosed |
| US-20120177587-A1 | METHOD OF COLOURING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE | L'ORéAL S.A. | 2012-07-12 | — | — | US | disclosed |
| US-8097044-B2 | Hair compositions comprising at least one disulfide direct dye and at least one alkaline hydroxide agent and simultaneous hair shaping and dyeing processes | L'OREAL S.A. (FR) | 2012-01-17 | — | — | US | disclosed |
| US-8038731-B2 | hair dyes contains naphthylimide thiol or disulphide groups; resistant and visible lightening effect on dark keratin fibres; cosmetics | L'OREAL S.A. (FR) | 2011-10-18 | — | — | US | disclosed |
| US-20090313769-A1 | METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE | L'OREAL S.A. (FR) | 2009-12-24 | — | — | US | disclosed |
| US-20090126755-A1 | Hair compositions comprising at least one disulfide direct dye and at least one alkaline hydroxide agent and simultaneous hair shaping an dyeing processes | L'OREAL S.A. (FR) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120177587-A1 | METHOD OF COLOURING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE | KRT18, DSG1, KRTCAP2 | CHRM2 4369/4885CHRM4 4064/4885CHRM5 3639/4885 |
| US-20090126755-A1 | Hair compositions comprising at least one disulfide direct dye and at least one alkaline hydroxide agent and simultaneous hair shaping an dyeing processes | KRT18, DSG1, ALPG | CHRM2 4532/4885CHRM4 4159/4885CHRM5 4111/4885 |
| US-20140033450-A1 | METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DEISULPHIDE DYE | KRT18, DSG1, DSP | CHRM2 4446/4885CHRM4 3988/4885CHRM5 3590/4885 |
| US-20130074276-A1 | METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE | KRT18, DSG1, KRTCAP2 | CHRM2 4386/4885CHRM4 4040/4885CHRM5 3531/4885 |
| US-20090313769-A1 | METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE | KRT18, DSG1, KRTCAP2 | CHRM2 4386/4885CHRM4 4040/4885CHRM5 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.