Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28211728 | 0.82 | LMNA (0.41) | NPC1KDM4EL3MBTL1CASP3SENP8 | |
| SCHEMBL27906353 | 0.81 | NR4A2 (0.47) | NPC1KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL8675316 | 0.81 | ALDH1A1 (0.43) | NPC1KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL1977339 | 0.79 | PDE5A (0.50) | KDM4ECASP3SENP8SENP7SENP6 | |
| SCHEMBL32677577 | 0.79 | PDE5A (0.50) | KDM4ECASP3SENP8SENP7SENP6 | |
| SCHEMBL28426349 | 0.79 | KDM4E (0.45) | NPC1KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL30598386 | 0.79 | KDM4E (0.53) | NPC1KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL1089189 | 0.79 | ALDH1A1 (0.55) | KDM4EL3MBTL1ALDH1A1LMNAMEN1 | |
| SCHEMBL27924406 | 0.77 | MPL (0.48) | MPL | |
| SCHEMBL14877433 | 0.76 | BACE1 (0.50) | NPC1KDM4EL3MBTL1CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102958930-B | [1,8] naphthyridine compounds as the 2,4- diaryl substitution for the kinase inhibitor to anticancer | 默克专利有限公司 | 2018-04-27 | — | — | CN | disclosed |
| WO-2012000595-A1 | 2,4- DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |
| US-5723413-A | Substituted naphthyridines and their herbicidal use | BASF AKTIENGESELLSCHAFT (DE) | 1998-03-03 | — | — | US | disclosed |
| EP-0669332-A2 | Substituted naphtyridines and their use as herbicides | BASF Aktiengesellschaft (DE) | 1995-08-30 | — | — | EP | disclosed |