Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 13/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367445 | 0.89 | TNIK (0.58) | TNIKMAPTTP53 | |
| SCHEMBL2367114 | 0.80 | TNIK (0.61) | TNIKMAPTTP53ALDH1A1 | |
| SCHEMBL2366707 | 0.77 | TNIK (0.62) | TNIKMAPTTP53 | |
| SCHEMBL2371218 | 0.75 | TNIK (0.57) | TNIKMAPTTUBB8BTUBB4ATUBB | |
| SCHEMBL3396902 | 0.75 | TNIK (0.69) | TNIKMAPTTP53 | |
| SCHEMBL13333398 | 0.75 | TNIK (0.69) | TNIKMAPTTP53 | |
| SCHEMBL2367226 | 0.74 | TNIK (0.61) | TNIKMAPTTP53ALDH1A1HPGD | |
| SCHEMBL2367413 | 0.74 | TNIK (0.63) | TNIKMAPTTP53ALDH1A1HPGD | |
| SCHEMBL2367058 | 0.74 | TNIK (0.60) | TNIKMAPTTP53 | |
| SCHEMBL15546809 | 0.73 | TNIK (0.60) | TNIKMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064111-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI (JP) | 2010-06-10 | — | — | WO | disclosed |