Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396222 | 1.00 | POLB (0.47) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL3394510 | 1.00 | POLB (0.47) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL3398082 | 0.86 | L3MBTL1 (0.51) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL684323 | 0.78 | BRD4 (0.44) | POLBCYP2C9CYP2C19FFAR2L3MBTL1 | |
| SCHEMBL2738682 | 0.77 | SLC6A4 (0.39) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL680697 | 0.75 | FFAR2 (0.41) | POLBKMT2AMEN1FFAR2L3MBTL1 | |
| SCHEMBL22288404 | 0.75 | POLB (0.55) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL16625002 | 0.75 | POLB (0.55) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL191373 | 0.75 | AKT1 (0.48) | POLBCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL191372 | 0.75 | AKT1 (0.48) | POLBCYP2C9CYP2C19KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160152574-A9 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2016-06-02 | — | — | US | disclosed |
| US-20140357644-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2014-12-04 | — | — | US | disclosed |
| US-8835434-B2 | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| EP-2247578-B1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20110065716-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-17 | — | — | US | disclosed |
| EP-2247578-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009089459-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357644-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | POLB 515/4885CYP2C9 1808/4885CYP2C19 1229/4885 |
| US-20110065716-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | POLB 464/4885CYP2C9 2022/4885CYP2C19 1293/4885 |
| US-20160152574-A9 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | POLB 515/4885CYP2C9 1808/4885CYP2C19 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.