Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818560 | 1.00 | MAPT (0.62) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6850607 | 0.87 | MAPT (0.54) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL13351489 | 0.81 | MAPT (0.62) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7146064 | 0.81 | MAPT (0.62) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL14432324 | 0.81 | MAPT (0.62) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL304325 | 0.80 | MAPT (0.56) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3174845 | 0.79 | ALDH1A1 (0.76) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9000553 | 0.79 | MAPT (0.65) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9665295 | 0.79 | MAPT (0.65) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3174841 | 0.79 | ALDH1A1 (0.76) | MAPTALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015703-A2 | NOVEL 6-O-SUBSTITUTED 15-MEMBERED 8A- AND 9A-LACTAMS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2010-02-11 | — | — | WO | disclosed |
| US-7419962-B2 | 3,6-bicyclolides | ENANTA PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| EP-1830858-A2 | 3, 6-BICYCLOLIDES | Enanta Pharmaceuticals, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20060142214-A1 | 3,6-bicyclolides | ENANTA PHARMACEUTICALS, INC. | 2006-06-29 | — | — | US | disclosed |
| WO-2006063039-A2 | 3, 6-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |
| US-6667338-B2 | For therapy of bacterial infections | ABBOTT LABORATORIES | 2003-12-23 | — | — | US | disclosed |
| US-20020142973-A1 | 9-Amino erythromycin derivatives with antibacterial activity | ABBVIE INC. | 2002-10-03 | — | — | US | disclosed |
| US-20020132782-A1 | 9-amino erythromycin derivatives with antibacterial activity | ABBOTT LABORATORIES | 2002-09-19 | — | — | US | disclosed |
| WO-2002057286-A2 | 9-AMINO ERYTHROMYCIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142214-A1 | 3,6-bicyclolides | ABCB11, CYP2B6, CYP3A7 | MAPT 3856/4885ALDH1A1 988/4885HPGD 715/4885 |
| US-20020142973-A1 | 9-Amino erythromycin derivatives with antibacterial activity | MRPL9, MRPL19, MRPL21 | MAPT 4554/4885ALDH1A1 3150/4885HPGD 3091/4885 |
| US-20020132782-A1 | 9-amino erythromycin derivatives with antibacterial activity | MRPL9, MRPL19, MRPL21 | MAPT 4554/4885ALDH1A1 3150/4885HPGD 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.