Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 10/20 | 0.64 |
| ▸ | TAS1R1 | Q7RTX1 | 10/20 | 0.64 |
| ▸ | TAS1R2 | Q8TE23 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29764007 | 0.78 | ALDH1A1 (0.59) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL23531256 | 0.78 | ALDH1A1 (0.59) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL23531255 | 0.78 | ALDH1A1 (0.59) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL3389867 | 0.78 | HTT (0.64) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL3393778 | 0.78 | HTT (0.64) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL702373 | 0.78 | TAS1R3 (1.00) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL702372 | 0.78 | TAS1R3 (1.00) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL8516550 | 0.78 | ALDH1A1 (0.72) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL3394672 | 0.78 | MTNR1A (0.51) | ALDH1A1 | |
| SCHEMBL3392185 | 0.78 | MTNR1A (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370530-B1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-1370530-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | Aventis Pharma Deutschland GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064565-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |