Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705658 | 0.95 | SLC2A1 (0.35) | HDAC3HDAC4HDAC1HDAC6ERCC5 | |
| Hydrochloric Acid SCHEMBL3397627 | 0.94 | SLC2A1 (0.34) | HDAC3HDAC4HDAC1HDAC6ERCC5 | |
| Trifluoroacetic Acid SCHEMBL3398157 | 0.90 | SERPINE1 (0.40) | SLC2A1PPARAESR1SERPINE1LSS | |
| SCHEMBL3713576 | 0.85 | SLC2A1 (0.42) | SLC2A1SERPINE1LSS | |
| Trifluoroacetic Acid SCHEMBL3398116 | 0.85 | PRMT1 (0.47) | SLC2A1ESR1SERPINE1 | |
| Hydrochloric Acid SCHEMBL3398480 | 0.84 | SLC2A1 (0.41) | SLC2A1SERPINE1LSS | |
| SCHEMBL3712620 | 0.84 | SLC2A1 (0.41) | SLC2A1SERPINE1LSS | |
| Hydrochloric Acid SCHEMBL3394437 | 0.83 | SLC2A1 (0.40) | SLC2A1SERPINE1LSS | |
| SCHEMBL3395496 | 0.81 | HDAC3 (0.35) | HDAC3HDAC4HDAC1HDAC6ERCC5 | |
| SCHEMBL3707693 | 0.80 | PRMT6 (0.40) | SLC2A1ABL1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |