Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712620 | 0.94 | SLC2A1 (0.41) | SERPINE1SLC2A1PRMT6LSSMMP2 | |
| Hydrochloric Acid SCHEMBL3394437 | 0.93 | SLC2A1 (0.40) | SERPINE1SLC2A1PRMT6LSSMMP2 | |
| SCHEMBL3713576 | 0.93 | SLC2A1 (0.42) | SERPINE1SLC2A1PRMT6LSSPTGDR2 | |
| Hydrochloric Acid SCHEMBL3398480 | 0.92 | SLC2A1 (0.41) | SERPINE1SLC2A1PRMT6LSSPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL3398116 | 0.91 | PRMT1 (0.47) | SERPINE1SLC2A1PTGER4ESR1 | |
| Trifluoroacetic Acid SCHEMBL3394740 | 0.90 | HDAC3 (0.38) | SERPINE1SLC2A1LSSESR1PPARA | |
| SCHEMBL3707693 | 0.87 | PRMT6 (0.40) | SERPINE1SLC2A1PRMT6PTGDR2 | |
| Hydrochloric Acid SCHEMBL3395841 | 0.86 | PRMT6 (0.39) | SERPINE1SLC2A1PRMT6PTGDR2 | |
| SCHEMBL3391536 | 0.85 | PRMT6 (0.39) | SERPINE1SLC2A1PRMT6LSSPTGDR2 | |
| SCHEMBL3709650 | 0.84 | PRMT1 (0.51) | SLC2A1PRMT6ESR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |