Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3593032 | 0.79 | MAP2K4 (0.50) | MAP2K4TRPA1GSK3BGPR84NOS1 | |
| SCHEMBL14738828 | 0.79 | MAP2K4 (0.63) | MAP2K4TRPA1GSK3BNOS1DYRK1A | |
| SCHEMBL4502873 | 0.78 | PDPK1 (0.60) | MAP2K4TRPA1GSK3BCHEK1JAK2 | |
| SCHEMBL15529807 | 0.76 | GSK3B (0.48) | MAP2K4TRPA1GSK3BGPR84NOS1 | |
| SCHEMBL2955244 | 0.76 | MAP2K4 (0.55) | MAP2K4TRPA1GSK3BGPR84NOS1 | |
| SCHEMBL30548014 | 0.76 | GSK3B (0.48) | MAP2K4TRPA1GSK3BGPR84NOS1 | |
| SCHEMBL3155790 | 0.76 | CHEK1 (0.50) | MAP2K4TRPA1GSK3BNOS1DYRK1A | |
| SCHEMBL1553907 | 0.76 | MAP2K4 (0.47) | MAP2K4TRPA1GSK3BGPR84NOS1 | |
| SCHEMBL31735799 | 0.76 | MAP2K4 (0.47) | MAP2K4TRPA1GSK3BGPR84NOS1 | |
| SCHEMBL1551001 | 0.72 | MAP2K4 (0.48) | MAP2K4TRPA1GSK3BDAOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |