SCHEMBL3395285

SCHEMBL3395285

OC(Nc1cnc(Br)cn1)c1c(-c2ccc(Cl)cc2Cl)nc2cnc(Br)cn12

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 5/20 0.38
SLC2A2 P11168 3/20 0.34
DPP4 P27487 1/20 0.33
MAPK14 Q16539 1/20 0.32
SLC2A1 P11166 1/20 0.32
TRPA1 O75762 2/20 0.31
CNR1 P21554 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3392032 0.86 MAPT (0.35) SLC2A1TRPA1
SCHEMBL3395134 0.82 MAPK14 (0.35) MAPK14
SCHEMBL14632158 0.81 GAA (0.30) MAPK14
SCHEMBL3360406 0.80 MEN1 (0.41) CRHR1SLC2A2DPP4MAPK14TRPA1
SCHEMBL3395179 0.80 TRPA1 (0.38) CRHR1SLC2A2DPP4MAPK14TRPA1
SCHEMBL3397222 0.78 MAPK14 (0.34) MAPK14
SCHEMBL3396264 0.77 CRHR1 (0.38) CRHR1SLC2A2DPP4MAPK14TRPA1
SCHEMBL3393708 0.76 ALDH1A1 (0.31)
SCHEMBL1691532 0.73 SLC2A2 (0.47) SLC2A2DPP4SLC2A1
SCHEMBL14632155 0.71 EGLN2 (0.39) CRHR1DPP4SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150239905-A1 IMIDAZOPYRIDINE COMPOUNDS BIOVITRUM AB (PUBL) (SE) 2015-08-27 US disclosed
US-20140206662-A1 Imidazopyridine Compounds PROXIMAGEN LTD. (GB) 2014-07-24 US disclosed
EP-2376490-B1 IMIDAZOPYRIDINE COMPOUNDS PROXIMAGEN LTD (GB) 2013-01-23 EP disclosed
WO-2010064020-A1 IMIDAZOPYRIDINE COMPOUNDS PROXIMAGEN LTD. (GB) 2010-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150239905-A1 IMIDAZOPYRIDINE COMPOUNDS SSB, MIF, IDO1 CRHR1 4422/4885SLC2A2 1914/4885DPP4 307/4885
US-20140206662-A1 Imidazopyridine Compounds SSB, NFKBIA, TPMT CRHR1 4208/4885SLC2A2 2135/4885DPP4 125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.