Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.45 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751298 | 0.89 | NPC1 (0.46) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL28211215 | 0.83 | TSPO (0.40) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL1927016 | 0.82 | ALDH1A1 (0.69) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL8124046 | 0.79 | TSHR (0.39) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL6999170 | 0.79 | TSHR (0.50) | ALDH1A1GLASMN1; SMN2TSHRKMT2A | |
| Carbamic Acid SCHEMBL6468271 | 0.77 | NPC1 (0.62) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL921192 | 0.76 | NR1H2 (0.46) | NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL28986105 | 0.75 | NPC1 (0.61) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL27658222 | 0.73 | TSHR (0.68) | NPC1ALDH1A1RAB9ATSHRMEN1 | |
| SCHEMBL7245951 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776349-B1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-06 | — | — | EP | claimed |