Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17911612 | 0.87 | MTNR1A (0.40) | ALDH1A1SMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL542640 | 0.83 | ACHE (0.58) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL12006 | 0.83 | LMNA (0.59) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| Bromide SCHEMBL27571347 | 0.81 | LMNA (0.57) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL17395129 | 0.80 | ACHE (0.55) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL23467899 | 0.79 | ACHE (0.54) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL15146352 | 0.79 | ACHE (0.54) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3169917 | 0.79 | ACHE (0.54) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL24086431 | 0.79 | ACHE (0.59) | ACHELMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4093572 | 0.79 | HSD17B10 (0.45) | LMNAALDH1A1GAAMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3681864-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Overseas S.à r.l. (LU) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019053634-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie S.à.r.l. (LU) | 2019-03-21 | — | — | WO | disclosed |
| EP-2935228-A1 | TRIAZOLONE COMPOUNDS AND USES THEREOF | Inception 2, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2822931-A1 | TRIAZOLONE COMPOUNDS AND USES THEREOF | Inception 2, Inc. (US) | 2015-01-14 | — | — | EP | disclosed |
| WO-2014099503-A1 | TRIAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION 2, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2013134562-A1 | TRIAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION 2, INC. (US) | 2013-09-12 | — | — | WO | disclosed |
| CN-101952260-B | 4, 5-dihydro-oxazol-2-yl amine derivatives | HOFFMANN LA ROCHE | 2013-02-13 | — | — | CN | disclosed |
| CN-101952260-A | 4, 5-dihydro-oxazol-2-ylamine derivs | HOFFMANN LA ROCHE | 2011-01-19 | — | — | CN | disclosed |
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |
| CN-100371319-C | Prepn and application of N-[2-(aryloxy)ethyl]-2-(arylthio) benzyl amine derivative | UNIV TIANJIN (CN) | 2008-02-27 | — | — | CN | disclosed |
| CN-1706820-A | Prepn and application of N-[2-(aryloxy)ethyl]-2-(arylthio) benzyl amine derivative | UNIV TIANJIN (CN) | 2005-12-14 | — | — | CN | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |