Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.73 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.66 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.52 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19539671 | 0.91 | YTHDC1 (0.63) | HDAC6HDAC1HDAC4YTHDC1HDAC2 | |
| SCHEMBL29445697 | 0.89 | YTHDC1 (0.78) | HDAC6HDAC1HDAC4YTHDC1HDAC2 | |
| SCHEMBL19539867 | 0.85 | YTHDC1 (0.74) | HDAC6HDAC1HDAC4YTHDC1HDAC2 | |
| SCHEMBL29366455 | 0.83 | HSP90AB1 (0.71) | HDAC6HDAC1HDAC4HDAC2HSP90AB1 | |
| SCHEMBL3389606 | 0.83 | HSP90AB1 (0.71) | HDAC6HDAC1HDAC4HDAC2HSP90AB1 | |
| SCHEMBL3272660 | 0.82 | ADORA2A (0.82) | ADORA2AADORA1 | |
| SCHEMBL29051728 | 0.82 | ADORA2A (0.60) | HDAC6HDAC1HDAC4YTHDC1HDAC2 | |
| SCHEMBL21076645 | 0.81 | YTHDC1 (0.58) | HDAC6HDAC1HDAC4YTHDC1HDAC2 | |
| SCHEMBL12857150 | 0.81 | HDAC6 (0.70) | HDAC6HDAC1HDAC4YTHDC1HDAC2 | |
| SCHEMBL21977307 | 0.81 | HDAC6 (0.69) | HDAC6HDAC1HDAC4HDAC2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
| US-4874862-A | Process for preparing guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | disclosed |